Article Writer- Minakshi Kumari, MSc. Biotechnology, RCA, Maharana Pratap University of Agriculture and Technology, Udaipur, Rajsthan(India)
Researchers representing the Wellcome Sanger Institute (The University of Cambridge) and MRC Cancer Unit demonstrated the role of steroidogenesis and T-Cells using transgenic steroidogenesis-reporter mouse line while fighting a tumor. Tumour signals T-Cells to produce steroids resulting in declined antitumor immunity.
When gene responsible for immunosuppressive steroids biosynthesis i.e., cyp11a1 were removed or switched off using a drug aminoglutethimide, there was a gradual slow down in tumor growth.
Researchers said that some preliminary data shows a similar response of human tissue against tumor formation and further research is needed to confirm it. And if it gets confirmed, it would pave a way towards the treatment of cancer by targeting the steroidogenesis pathway to prevent antitumor immunosuppression and will save human lives.
Mahata, B., Pramanik, J., van der Weyden, L. et al. Tumors induce de novo steroid biosynthesis in T cells to evade immunity. Nat Commun 11, 3588 (2020). https://doi.org/10.1038/s41467-020-17339-6