Article Writer- Minakshi Kumari, MSc. Biotechnology , RCA, Maharana Pratap University of Agriculture and Technology ,Udaipur, Rajsthan(India)
Arecent study by an international research team has shown that the brain protects its neurons from viral infection. Vesicular Stomatitis Virus (VSV), a potentially lethal virus infects both livestock and humans by transmitting sensory input from nose to the brain.
The brain uses Microglia (specific immune cells) against viruses to neutralizes it without damaging the neurons. Microglia capture the virus from nearby neurons and takes to other immune cells where it triggers the release of antiviral proteins. In this way, Microglia help to control the viral infection.
These results may help to understand other respiratory viruses (eg. SARS-CoV2) and their impact on the brain. Also, it has been concluded that treatments of immune cells and Microglia help to protect the brain and neurons against nasal infection.
Moseman, E. A. et al. T cell engagement of cross-presenting microglia protects the brain from nasal virus infection. Sci. Immunol.5, eabb1817 (2020)