Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (Mtb) in humans. It is one of most life-threating infectious diseases worldwide. One third(1/3rd ) of the world population is latently infected by Mtb. According to new research Epigallocatechin gallate (EGCG), one of the principle polyphenolic compounds found in the leaves of the green tea plant (Camellia sinensis), is effective against Mycobacterium tuberculosis. A new report published in the journal Scientific Reports in November 2019. During infection, Mtb undergoes a wide range of metabolic changes, which correlate with either replicative growth or non-replicative persistence. Addition of 750 nM of EGCG reduced ATP synthesis of the I66M mutant(a Mycobacterium mutant) IMVs significantly, confirming that the mycobacterial F-ATP synthase is the enzyme target. This research discovered that EGCG is the novel F-ATP synthase inhibitor.
Reference- W. Saw et al. 2019. Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis. Sci Rep 9, 16759; doi: 10.1038/s41598-019-53107-3