Medical Biotechnology

Medical biotechnology is defined as the application of biotechnological tools and techniques in which use of living cells, tissue, organs or bodies to research and produce diagnostic and pharmaceutical products that can be used for the diagnosis , prevention and treatment of diseases.

21th  century is the fast growing time of medical biotechnology. Many national and international companies, research institute , government bodies are taking interest in research and development in medical biotechnology.

Medical biotechnology plays critical roles during  emerging of new  chronic diseases either microbials or non-microbials.One of the best example of Ebola disease and their causing agent is Ebola virus. The first drug of Ebola disease is ZmappTm  which is developed by Mapp pharmaceuticals corporation and Bioleaf corporation. Both are international biotech companies.

Medical biotechnology is related our health, development of new drugs , work against bacterial, fungal , viral, cancer diseases and so on.

Contents of Medical Biotechnology:

Basic technologies                                                        

Molecular Cloning

DNA amplification and sequencing

Genomics

RNA interference

Gene therapy

Phage therapy

Concepts of immunology

Immune system and immune response

Cell mediated and humoral immunity

Immunological techniques

Stem cell therapy and bioengineered tissues

Antibiotics and vaccines

Human diseases

Causes and reason

Infectious and non-infectious

Genetic and autoimmune

Transmission of diseases

Diagnosis

Genetic basis of diseases

Chromosomal disorders

Gene mapping

Single gene and polygenic disorders

Mitochondrial disorders

Gene clustering

Immune Pathogenesis

Models of immune system defects

Inflammation and immune hypersensitivity disorders

Immunodeficiency and autoimmune disorders

Immunotherapy

Microbial Pathogenesis

Bacterial Infections

Bacterial genetics

Microbial biotransformation

Viral Infections

Antiviral drugs

Drug-resistance

Modulating Gene Expression

Recombinant DNA technology

Manipulation of gene expression in prokaryotes

Heterologous protein production in eukaryotic cells

Directed and random mutagenesis

Translational and transcriptional regulations

DNA shuffling

Cell and tissue engineering

Animal cell culture

Biomaterials

Stem cell technology

iPSCs and ESCs

Genetic engineering of plants

Molecular pharming and edible vaccines

Molecular diagnostics

Immunological approaches to detect protein biomarkers of disease

DNA-based approaches to disease diagnosis

Detecting RNA signatures of diseases

Fluorescence in situ hybridization

Genetic fingerprinting

Protein Therapeutics

Pharmaceuticals

Engineered bacteriophages

Recombinant antibodies

Enzymes

IL-10 modulations

Nucleic acid therapeutic agents and human gene therapy

Targeting specific mRNAs and DNAs

Viral and non-viral delivery systems

Prodrug activation therapy

Severe combined immunodeficiency

Vaccines

Advantages and limitations

Peptide vaccines

Dendritic cell vaccines

DNA vaccines

Attenuated and subunit vaccines

Adjuvants

Systems biology and evaluation of vaccines